In the 19th century, feudal Japan was only a few steps away from the Meiji Revolution. A low-class samurai turned revolutionly fighter named Amane desperately attempts to elude the clutches of the Shogunate's Special Police Unit--the infamous Shinsengumi. Fatally injured from sword wounds given to him by his former colleagues in arms, Amane somehow managed to roll upon the small shack of a tattooist named Baikou. Realizing that Amane's life was in deep peril, the tattoo artist decided to etch a curse in ink onto the dying Amane's skin. And soon a forbidden sanskrit marking was now forever emblazened on Amane's hand. The technique Baikou utilized is called an "Demonic Interjection." Amane survived the ordeal, but was then burdened with the fact that he was now an immortal. With the miserable knowledge of being exiled from the rest of human life, Amane would then resign himself to became an apprentice to Baikou in hope to evenutally master a range of tattooing techniques which would ultimately control the tattoo bearer's life. From this day on, Amane would be known as "Enma," named after the Buddhist gatekeeper of hell. He must now live forever granting others new life while desperately seeking the monster like him who is at the source of his life-long problems.